Stem Cell Therapy for Brain Injury

The Situation with Brain Injuries

Traumatic brain injury is one complex condition characterizing a wide spectrum of clinical symptoms that are caused by a prior insult to the brain majorly through external mechanical force to the skull. Notably, the United States records a total of 1.7 million affected people and 50, 000 deaths per year due to traumatic brain injury which makes it one of the leading causes of mortality among the young adult generation in the developed world. The pathophysiology of Traumatic brain injury is complex, consisting of delayed injury. The acute phase of brain injury majorly sees the destruction of brain tissues such as neurons, glia, endothelial cells and the latter which makes up the blood-brain barrier. The delayed phase is more aggravating as the toxins released from the damaged cells release cascades in neighbouring cells and tissues, this eventually leads to the exacerbation of the primary injury. Correlatively, the pathophysiology involves the breakdown of brain barriers, the spread of neuroinflammation, axonal injury diffusion and subsequent neurodegeneration.

Conventional Measures to Treat Brain Injury

Traumatic brain injuries are clinically treated using noninvasive brain stimulation, hyperbaric oxygen therapy, behavioural therapies, and task-oriented electrical stimulation.

Stem Cell Therapy as an Alternative Method to Treat Brain Injury

Traumatic brain injury leads to significant brain stress which makes it impossible to appropriately maintain cognitive abilities. In as much as other body organs such as the skin can self-renew, the brain does not regenerate. StemFinityCord has taken decades of specializing in assessing the impact of neural stem cells as a regenerative effort of the brain. Since the inception of the procedure in 1960, our specialists have evaluated the tests and trials done and continues to do more tests proving the efficacy of the treatment of brain injuries. It is worth pointing out that the pathophysiology and molecular mechanism that underlie the debilitating condition involves potential therapeutic strategies such as those of stem cells. The specialists use these merging therapeutic strategies to improve the recovery of brain injuries and reverse the damage. The allogeneic mesenchymal stem cell transplantation has been proven to improve the proliferation of endogenous cells and the promotion of immature neural differentiation in injured brain regions. After a brain injury, exogenous stems stimulate the proliferation of endogenous neural stem cells; this is followed by induction of neurogenesis.

How Stem Cell Treatment for Brain Injury Works

The type of stem cells that have profoundly been implemented into practice are mesenchymal stem cells. They are derived from a variety of tissues, mostly the umbilical cord Wharton jelly cells and can characteristically differentiate also into non-mesenchymal tissues such as neural cells. Upon administration, mesenchymal stem cells also lead to an increase in proliferation and differentiation of pre-existing neural stem cells. Our specialists define these mechanisms to be directly related to the release of chemokines by mesenchymal stem cells or through the indirect activation of the surrounding astrocytes. Mesenchymal stem cells can suppress lymphocytes and reduce the proliferative response of lymphocytes which makes them useful in reducing the secondary effects of traumatic brain injuries.

Mesenchymal stem cells upregulate TIMO3 gene expression. This gene is a metalloprotease inhibitor that decreases the permeability of the blood-brain barrier in individuals who have experienced a traumatic brain injury. Notably, the use of mesenchymal stem cells in the treatment of brain injury is also based on their ability to cross the blood-brain barrier through Para-cellular pathways.

Research on Stem Cell Therapy for Brain Injuries

The regenerative capacity of neural stem cells found in the adult brain is vital in responding to traumatic brain injuries. As noted by Hindawi, the manipulation of various growth factors shows significant efficacy in the promotion of neurogenesis. Besides the differential activity of mesenchymal stem cells, they can selectively migrate into injured tissues in traumatic brain injury models with the subsequent differentiation in neurons and astrocytes. This is also attributed to the subsequent improvement in the motor function of subjects as noted by Hindawi. The mechanism of action of this process is related to growth factors, chemokines and vascular adhesion molecules which allows for the adhesion of mesenchymal stem cells to the endothelium of the injured tissues.

StemFinityCord also takes into account the most recent approach of stem cell therapy using genetically modified mesenchymal stem cells which are used for the production of chemokines and cytokines growth factors. These growth factors enhance the neural cell after an injury which prompts a new type of therapeutic procedure for brain injury without the actual transplantation of mesenchymal stem cells.

The Process

StemFinity Cord offers you with a minimally invasive therapeutic process. The procedure is usually carried out in outpatient conditions in which the recovery may vary from patient to patient. Stem cell therapy procedure at StemFinityCord involves the extraction and cultivation of stem cells in the quantities recommended by the medical specialists and backed up by scientific evidence from the umbilical cord Wharton jelly.

The unique blend of stem cells and regenerative cells are isolated and prepare for delivery using proprietary closed or sterile fully automate CGMP cell processing system. While preparation of cells takes around 14 days, the actual introduction of cells to the patient’s body usually doesn’t take more than 3-4 hours. Before the infusion, the medics administer mannitol to facilitate the cell crossing of the blood-brain barrier as this ensures a more effective cell delivery.

The stem cells are intravenously administered based on the individualized treatment plan of the patient. StemFinityCord also offers a post-operative session that involves a brief physical examination and discharge plan that is discussed. Just before we clear you to go home, our physicians review your recommendation for post-treatment and follow up on a communication plan.

Get in Touch and Let’s Discuss How We Can Help You

Do not let brain injuries limit your life or the life of your loved one. We are here to help you regain your long-lost life capabilities as we see you through a very cost-effective and minimally invasive medical procedure. Contact us and let us take you through; from the severity of your condition to how the therapeutic procedure works and the recovery process. We are here for you.

References
  • Okyanos. (2019). Traumatic Brain Injury. Retrieved April 10, 2020.

  • Reis. C. et al. (2017). Traumatic Brain Injury and Stem Cell: Pathophysiology and Update on Recent Treatment Modalities. Hindawi. Stem Cell International. Retrieved April 10, 2020.

  • Rolfe. A & Sun. D. (2015). Stem Cell Therapy in Brain Trauma. Brain Neurotrauma: Molecular, Neuropsychological, and Rehabilitation Aspects. NCBI. Retrieved April 10, 2020.

  • Zhou. Y. et al. (2019). The advance of Stem Cell Treatment for Traumatic Brain Injury. Frontiers in Cellular Neuroscience. Retrieved April 10, 2020.

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