Stem Cell Therapy for Heart Failure
The Bright Side
For more than six decades empirical research has shown that psychological risk factors such as lack of socio support, family life, socio-economic, stress at work, hostility, anxiety, and depression contribute both to the risk of developing coronary heart diseases and the worsening of clinical course and prognosis in patients with heart failure.
These factors largely act as barriers to the treatment process in terms of adherence and the efforts to improving the lifestyle in patients. In clinical practice, psychological risk factors should, therefore, be assessed by clinical interview or standardized questionnaires and relevance concerning the quality of life. The medical outcome should be discussed with the patients.
With the above factors, we believe that interventions boosting positive thoughts help a lot in improving the health of a patient. This is because heart failure is one disorder that has proven difficult to treat using conventional measures but can be managed through stem cell therapy and lifestyle changes which largely are contributed by the person himself.
How Stem Cell Therapy Works for Heart Failure
The treatment of postinfarction heart failure is one medical field that remains to be elusive. Regenerative surgery is, therefore, one of the latest therapeutic surgery novels. It involves the transplantation of immature progenitor cells in the affected hearts which are then intended to lead to the production of new blood vessels and muscle cells of the cardiac cavity.
Stem cell therapy offers a very promising way of treating heart failure – the procedure involves using stem cells to promote the regeneration of heart muscle and blood vessel cells.
Our specialists reckon that the primary mechanism intricated in stem cell therapy is through paracrine effects. This involves the release of cytokines, chemokines and growth factors responsible for the inhibition of apoptosis and fibrosis, enhancing contractility and activating endogenous regenerative mechanisms by the endogenous circulation or site-specific stem cells.
We have also taken a newer direction for clinical trials that include the use of stem cells that are capable of cardiac lineage such as endogenous cardiac stem cells.
Unlike many other stem cell therapies, for heart failure, human bone marrow has insufficient cells to help in organ repair hence aspiration; the isolation, selection of a certain phenotype of cells and in vitro expansion is done.
We therefore primarily use mesenchymal stem cells derived from umbilical cords since they have proven to normally function after freezing preservation.
This gives mesenchymal stem cell treatment an added therapeutic advantage since they serve as allogeneic graft eliminating the need for bone marrow harvesting which many patients find unpleasant.
StemFinity Cord also implements the commercial production of the Mesenchymal stem cells; using good manufacturing practice (GMP) to separate hematopoietic and mesenchymal stem cells from umbilical cord Wharton Jelly. Allogenic mesenchymal stem cells are cultured under GMP conditions fetal bovine serum-supplemented media, they are then grown to a master cell bank stage and thereafter expanded before being used in the treatment process.
Studies and Research
Investigative evidence from many animal experiments has substantially shown that the transplantation of specific stem cells may lead to the production of new cardiomyocytes and coronary blood vessels as noted in Methodist DeBakey Cardiovascular Journal. The journal also highlights that new generation clinical trials utilize specific cell types that are known to produce cardiac lineage cells focusing on repairing of acute or chronic myocardial damage due to infarction. Studies reveal that the use of stem cell therapy is effective in the improvement of the function of the left ventricle and occasional attenuation of left ventricle dilation. According to Cleveland Clinic, a study conducted to carefully evaluate more promising approaches has shown that medical researchers incorporate the approach of:
- Administering more highly selected stem cells from a donor around the time of the heart attack.
- Giving the patient’s own cardiac stem cells after an attack
- Administering a highly selected, non-cardiac stem cell from a donor later after an attack
These standard operations are in line with our services as we also implement them in administering care to our patients.
Medical procedures, just like any other processes are subject to side effects since there is always a disparity in the dosage, the severity of the patient’s underlying condition and overall response which is determined by the immune response.
Several studies have shown that stem cell therapy is effective in managing heart failure, however, stem cells are affected by inflammatory environments and thus develop inflammatory properties. This makes the treatment to be approached with caution as we believe that just like any other recommended drugs, the procedure can lead to adverse side effects.
StemFinityCord understands this and deeply cares for you, for that reason, our specialists use only premium stem cells obtained from healthy donors.
Advantages of Stem Cell Therapy for Heart Failure
- Mesenchymal stem cells are immune privileged hence are not prone to rejection making Human Leukocyte Antigen matching unnecessary
- There is a precise selection of stem cells with the best anti-inflammatory activity and immune-modulating capacity and regenerative ability.
- Administering allogeneic stem cells can be done several times in uniform dosages.
- Umbilical cord tissues provide an abundant supply of mesenchymal stem cells making the process more pleasant. Our medical team has also established that mesenchymal stem cells from umbilical cord tissues are more robust and have higher efficacy compared to other stem cell sources.
- Stem cell therapeutic procedure eliminates the need to administer chemotherapeutic drugs such as Granulocyte colony-stimulating factor (G-CSF) to help stimulate the bone marrow to release stem cells and granulocytes into the bloodstream.
With the growing number of cases of heart failure, the need for regenerative therapy is one medical science field that has sparked many types of research and studies. StemFinityCord is one of such organizations that is geared to helping you manage heart failure in a more friendly and efficient way without involving the need to do the conventional transplant. Reach out to us and let us take you through the process of showing you just how much stem cells can be of use in managing your heart failure.
Michler. R. E. MD. (2013). Stem Cell Therapy for Heart Failure. Methodist DeBakey Cardiovascular Journal. Retrieved April 6, 2020.
Whiteman. H. (2017). Heart failure: Stem cell therapy may worsen heart damage. Medical News Today. Retrieved April 6, 2020.
Curfman. G. MD. (2019). Stem Cell Therapy for Heart Failure. An Unfulfilled Promise?
Cleveland Clinic. (2019). Heart Disease: Stem Cell Therapy. Retrieved April 6, 2020. JAMA Network. Retrieved April 6, 2020.
Stem Cell Institute. (2017). Stem Cell Therapy for Heart Failure. Retrieved April 6, 2020.